Bcr-Abl1 Transcript Variants in Chronic Myeloid Leukemia Patients:  Relationship with Routine Hematological Parameters

Grace Sela; Adi Koesoema Aman; Malayana R. Nasution

doi:10.36590/jika.v7i3.1644

Authors

Grace Sela Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia
Adi Koesoema Aman Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia
Malayana R. Nasution Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.36590/jika.v7i3.1644

Keywords:

bcr-abl1 variants, chronic myeloid leukemia, hematological profile

Abstract

Chronic myeloid leukemia (CML) was a myeloproliferative neoplasm characterized by the Philadelphia chromosome resulting from the BCR-ABL1 translocation. The most common BCR-ABL1 transcript variants were b2a2 and b3a2, which encoded the p210 protein with increased tyrosine kinase activity. This study was an analytical observational study with a cross-sectional design using retrospective data obtained from medical records. The study analyzed the relationship between BCR-ABL1 transcript variants and routine hematological parameters (hemoglobin, leukocyte count, and platelet count) among CML patients at Adam Malik General Hospital from 2020 to 2024 using a total sampling method. A total of 38 patients met the inclusion criteria, of whom 71,1% had the b3a2 variant and 28,9% had the b2a2 variant. Males predominated (60,5%), with a mean age of 28,37 ± 16,23 years. Leukocyte counts were significantly lower in patients with the b3a2 variant than in those with the b2a2 variant (p = 0,045), whereas hemoglobin and platelet levels showed no significant differences. A statistically significant relationship was found between leukocyte count and BCR-ABL1 transcript variants, while no significant relationship was observed between hemoglobin or platelet levels and transcript variants. The study highlighted the potential association between BCR-ABL1 transcript variants and leukocyte count in CML patients.

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Author Biographies

Grace Sela, Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

Adi Koesoema Aman, Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

Malayana R. Nasution, Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

Program Studi Kedokteran, Fakultas Kedokteran, Universitas Sumatera Utara, Medan, Indonesia

https://scholar.google.com

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