Moringa Leaf Extract Cream (Moringa oleifera L.)for Incision Wound Healing in White Rats
DOI:
https://doi.org/10.36590/jika.v7i2.1267Keywords:
krim, daun kelor, luka sayatAbstract
The use of traditional medicinal plants is part of cultural heritage that holds great potential in supporting public health. Moringa leaves are known to accelerate the healing of incision wounds due to their bioactive compounds, including flavonoids, saponins, and terpenoids, which play a role in tissue recovery. This study aimed to evaluate the effectiveness of herbal cream containing Moringa leaf extract at concentrations of 2% w/w and 4% w/w in promoting the healing of incision wounds in white rats, assessed by wound closure length and histopathological examination of inflammatory cells. A true experimental design was applied in this research. The results showed that the Moringa leaf extract cream facilitated wound healing on the dorsal area of white rats within seven days and revealed a significant difference compared to the negative control group. Histopathological analysis demonstrated that treatment with 2% w/w and 4% w/w Moringa extract cream resulted in inflammatory cell counts of fewer than 50. In conclusion, herbal cream formulations containing 2% w/w and 4% w/w Moringa leaf extract are effective in healing incision wounds in white rats.
Downloads
References
Abdullah, S.S., Saad, A.A., Bota, M., Adnan, J., 2024. Uji Efek Penyembuhan Luka dari Sediaan Gel Ekstrak Buah Merah (Pandanus conoideus Lamk) pada Luka Sayatan Mencit (Mus musculus). Jurnal Farmasi Pelamonia 4(1), 1-6. https://www.ojs.iikpelamonia.ac.id/index.php/Pharmacy/article/view/569
Al-Ghanayem, A.A., Alhussaini, M.S., Asad, M., Joseph, B., 2022. Effect of Moringa oleifera Leaf Extract on Excision Wound Infections in Rats: Antioxidant, Antimicrobial, and Gene Expression Analysis. Molecules 27(14), 1-18. https://doi.org/10.3390/molecules27144481
Ali, A., Garg, P., Goyal, R., Kaur, G., Li, X., Negi, P., Valis, M., Kuca, K., Kulshrestha, S., 2021. A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing. Plants 10(1), 1-13. https://doi.org/10.3390/plants10010025
Ardiani, R., 2023. Formulasi dan Uji Efektivitas Sediaan Krim Ekstrak Daun Kelor (Moringa oleifera) terhadap Penyembuhan Luka Bakar pada Tikus Putih Jantan (Rattus novergicus). Jurnal Farmasi dan Herbal 5(2), 1-23. https://ejournal.delihusada.ac.id/index.php/JPFH/article/view/1212
Devi, G., Gopinath, L., Suryadevara, N., 2017. Qualitative and Quantitative Analysis of Secondary Metabolites of Moringa oleifera and its Anticancer Activity. International Journal of Advances in Interdisciplinary Research 4(1), 1-6. https://www.researchgate.net/publication/320754353_Qualitative_and_Quantitative_Analysis_of_Secondary_Metabolites_of_Moringa_Oleifera_and_its_Anticancer_Activity
Dira, M.A., Dewi, K.M.C., 2022. Formulasi dan Evaluasi Krim Body Scrub Kombinasi Ekstrak Moringa oleifera dan Oryza sativa sebagai Eksfolian. Jurnal Mandala Pharmacon Indonesia 8(2), 307-317. https://jurnal-pharmaconmw.com/jmpi/index.php/jmpi/article/view/242
Djuddawi, M.N., Haryati, H., Kholidha, A.N., 2019. Uji Efektivitas Ekstrak Serai (Cymbopogon citratus) terhadap Penyembuhan Luka Sayat pada Mencit Putih. Jurnal Surya Medika 5(1), 13-21. https://journal.umpr.ac.id/index.php/jsm/article/view/942
Fadillah, S., Aji, D., Anggraeni, D., 2023. Pemanfaatan Ekstrak Daun Kelor (Moringa oleifera Lamk) untuk Penyembuhan Luka Tikus Ovariektomi yang Diberi Diet Tinggi Lemak. Jurnal Sain Veteriner 41(1), 63-69. https://doi.org/10.22146/jsv.77161
Herdiani, M., Pramasari, C.N., Purnamasari, C.B., 2022. Pengaruh Ekstrak Daun Kelor (Moringa oleifera Lam.) terhadap Penyembuhan Luka. Mulawarman Dental Journal 2(1), 16-29. https://doi.org/10.30872/MOLAR.v2i1.5533
Hertian, R., Muhaimin, M., Kasmadi, F.S., 2021. Uji Efektivitas Ekstrak Daun Ekor Naga (Rhaphidohora pinnata (L.f) Schott) terhadap Penyembuhan Luka Sayat pada Mencit Putih Jantan. Indonesian Journal of Pharma Science 3(1), 11-20. https://online-journal.unja.ac.id/IJPS/article/view/13593?articlesBySimilarityPage=2
Husni, P., Pratiwi, A.N., Baitariza, A., 2019. Formulasi Krim Ekstrak Etanol Daun Kelor (Moringa oleifera Lamk). Jurnal Ilmiah Farmasi Farmasyifa 2(2), 101-110. https://doi.org/10.29313/jiff.v2i2.4796
Marwansyah, M., Sajidah, A., 2020. Pengaruh Pemberian Ekstrak Daun Salam (Syzygium polyanthum) terhadap Penyembuhan Luka Insisi pada Tikus Putih (Rattus norvegicus Strain Wistar). Jurnal Citra Keperawatan 8(1), 7-15. https://doi.org/10.31964/jck.v8i1.135
Mufidah, N., Sunarsih, E.S., Dini, I.R.E., 2023. Uji Aktivitas Penyembuhan Luka Ekstrak Etanol Herba Meniran (Phyllanthus niruri L.) pada Kelinci Jantan (Oryctolagus cuniculus). Journal of Research in Pharmacy 3(1), 65-73. https://doi.org/10.14710/genres.v3i1.17362
[Riskesdas] Riset Kesehatan Dasar., 2018. Laporan Riskesdas 2018 Nasional. Lembaga Penerbit Balitbangkes Kemenkes RI: Jakarta.
Teclegeorgish, Z.W., Aphane, Y.M., Mokgalaka, N.S., Steenkamp, P., Tembu, V.J., 2021. Nutrients, Secondary Metabolites and Anti-Oxidant Activity of Moringa oleifera Leaves and Moringa-Based Commercial Products. South African Journal of Botany 142, 409-420. https://doi.org/10.1016/j.sajb.2021.07.008
Tofiq, S.A., Azeez, H.A., Othman, H.H., 2021. Wound Healing Activities of Moringa oleifera Leaves Extract Cultivated in Kurdistan Region-Iraq. Jordan Journal of Biological Sciences 14(4), 637-645. https://doi.org/10.54319/jjbs/140403
Wintoko, R., Yadika, A.D.N., 2020. Manajemen Terkini Perawatan Luka. Jurnal Kedokteran Universitas Lampung 4(2), 183-189. https://juke.kedokteran.unila.ac.id/index.php/JK/article/view/2893
Yunita, E., Permatasari, D.G., Lestari, D., 2020. Aktivitas Antibakteri Ekstrak Daun Kelor terhadap Pseudomonas Auroginosa. Jurnal Ilmiah Farmako Bahari 11(2), 189-195. https://journal.uniga.ac.id/index.php/JFB/article/view/886/822
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Made Asmarani Dira, Lia Puspitasari
This work is licensed under a Creative Commons Attribution 4.0 International License.
