Clitoria Ternatea Antioxidant Reduces Serum MDA in  Leprosy Patients with Reversal Reactions

Fitri Aulia Ananda; Novi Kusumaningrum; Muflihatul Muniroh; Farmaditya EP Mundhofir; Renni Yuniati

doi:10.36590/jika.v5i2.411

Authors

Fitri Aulia Ananda Departemen Biomedik, FK Universitas Diponegoro, Semarang, Indonesia
Novi Kusumaningrum Departemen Dermatologi dan Venerologi, FK Universitas Diponegoro, Semarang, Indonesia
Muflihatul Muniroh Departemen Fisiologi, FK Universitas Diponegoro, Semarang, Indonesia
Farmaditya EP Mundhofir Departemen Histologi, FK Universitas Diponegoro, Semarang, Indonesia
Renni Yuniati Departemen Dermatologi dan Venerologi, FK Universitas Diponegoro, Semarang, Indonesia

DOI:

https://doi.org/10.36590/jika.v5i2.411

Keywords:

adjuvant, clitoria ternatea, leprosy, MDA, reversal reaction

Abstract

Leprosy reaction type 1 or reversal reaction is a clinical condition in leprosy patients that can occur when the patient receives MDT treatment. Patients with a reversal reaction have high MDA levels due to oxidative stress caused by inflammation and bacterial activity. The aim of this study was to determine the effectiveness of the antioxidant C. ternatea in reducing serum MDA of leprosy patients with reversal reaction. The research method used an experimental study with a randomized single blind controlled trial design to compare 2 groups (11 subjects each). Group 1 was the control group which was only given standard prednisolone therapy. Group 2 is the treatment group that was given standard therapy plus adjuvant C. ternatea flower extract 2gr/day for 1 month. Blood sampling was carried out before and after treatment in each group to test MDA levels using the ELISA method. Statistical analysis of differences in MDA levels used the Mann Whitnet test. The difference in pretest-posttest MDA levels in the control group had a median of 0,33 pg/ml (-0,05-1,55) pg/ml, while the difference in pretest-posttest MDA levels in the treatment group was 0,89 pg/ml (0,55-4,44) pg/ml with a value of p=0,020 (p-value<0,05). The difference in pretest-posttest MDA levels in the treatment group was higher than the control group. This shows that standard therapy and adjuvant C. ternatea extract are more effective in reducing MDA levels in patients with type 1 leprosy reaction than just standard therapy.

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Author Biographies

Fitri Aulia Ananda, Departemen Biomedik, FK Universitas Diponegoro, Semarang, Indonesia

Departemen Biomedik, FK Universitas Diponegoro, Semarang, Indonesia

Novi Kusumaningrum, Departemen Dermatologi dan Venerologi, FK Universitas Diponegoro, Semarang, Indonesia

Departemen Dermatologi dan Venerologi, FK Universitas Diponegoro, Semarang, Indonesia

https://scholar.google.co.id

Muflihatul Muniroh, Departemen Fisiologi, FK Universitas Diponegoro, Semarang, Indonesia

Departemen Fisiologi, FK Universitas Diponegoro, Semarang, Indonesia

https://scholar.google.co.id

Farmaditya EP Mundhofir, Departemen Histologi, FK Universitas Diponegoro, Semarang, Indonesia

Departemen Histologi, FK Universitas Diponegoro, Semarang, Indonesia

https://scholar.google.com

Renni Yuniati, Departemen Dermatologi dan Venerologi, FK Universitas Diponegoro, Semarang, Indonesia

Departemen Dermatologi dan Venerologi, FK Universitas Diponegoro, Semarang, Indonesia

https://scholar.google.co.id

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