The Antityrosinase Activity of Mitragyna speciosa  Korth Leaf Ethanolic Extract

Normaidah Normaidah; Maslia Rahmah; Hayatun Izma; Fadlilaturrahmah Fadlilaturrahmah; Anna Khumaira Sari

doi:10.36590/jika.v6i1.761

Authors

Normaidah Program Studi Pendidikan Profesi Apoteker, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Maslia Rahmah Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Hayatun Izma Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Fadlilaturrahmah Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Anna Khumaira Sari Program Studi Pendidikan Profesi Apoteker, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

DOI:

https://doi.org/10.36590/jika.v6i1.761

Keywords:

kratom, melanogenesis, enzyme inhibitory activity, L-DOPA

Abstract

The kratom plant (Mitragyna speciosa Korth) is a the plant that is traditionally used to soften the skin. Kratom leaves have very strong antioxidant activity so they are predicted also to have anti-tyrosinase activity. The potential inhibition of tyrosinase enzyme activity is thought to come from the content of flavonoid compounds, polyphenols, steroids, tannins, and quinones. This research aims to determine the tyrosinase inhibitory activity of ethanol extract of M. speciosa leaves. The inhibitory activity of the tyrosinase enzyme using L-DOPA as substrate and kojic acid as positive control. Antityrosinase testing was carried out by in vitro method using UV-vis spectrophotometer through determination of IC₅₀ value. The results of the antityrosinase activity test of ethanol extract of M. speciosa leaves showed an IC₅₀ value of 2117.708 ppm. The ethanol extract of M. speciosa leaves is scientifically proven to have antityrosinase activity with a weak category.

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Author Biographies

Normaidah, Program Studi Pendidikan Profesi Apoteker, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

Program Studi Pendidikan Profesi Apoteker, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

https://scholar.google.co.id

Maslia Rahmah, Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

Hayatun Izma, Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

https://scholar.google.com

Fadlilaturrahmah, Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

Program Studi Farmasi, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

https://scholar.google.com

Anna Khumaira Sari, Program Studi Pendidikan Profesi Apoteker, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

Program Studi Pendidikan Profesi Apoteker, Universitas Lambung Mangkurat, Banjarbaru, Indonesia

https://scholar.google.com

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