Analysis of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte  Ratio in Dengue-Infected Patients

Nurul Adha Sari; Sri Julyani; Muhammad Wirawan Harahap; Irmayanti Haidir Bima; Abdul Mubdi Ardiansar Arifuddin Karim

doi:10.36590/jika.v7i2.1375

Authors

Nurul Adha Sari Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Muslim Indonesia, Makassar, Indonesia
Sri Julyani Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia
Muhammad Wirawan Harahap Departemen Anestesi, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia
Irmayanti Haidir Bima Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia
Abdul Mubdi Ardiansar Arifuddin Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

DOI:

https://doi.org/10.36590/jika.v7i2.1375

Keywords:

biomarkers, dengue infection, neutrophil-to-lymphocyte ratio

Abstract

Dengue infection, caused by the dengue virus and transmitted by Aedes mosquitoes, remains a significant public health issue in Indonesia. The ability to identify reliable biomarkers for assessing disease severity is critical for improving clinical management. This study aimed to evaluate the relationship between the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) as potential biomarkers of severity in dengue infection. An observational cross-sectional design was employed, analyzing 76 dengue cases at RSAU dr. Dody Sardjoto. Data were collected from medical records of patients during the critical fever period (days 4-7). The majority of patients were male and adult, with a higher incidence of Dengue Hemorrhagic Fever (DHF). Statistical analysis showed no significant correlation between NLR and PLR with disease severity (p-value >0,05), although a positive correlation between NLR and PLR was observed. However, neither NLR nor PLR effectively predicted hospitalization duration. These results suggest that while NLR and PLR reflect immune responses in dengue infection, they are not suitable biomarkers for assessing disease severity. Further research is needed to identify more reliable biomarkers for better management of dengue infection.

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Author Biographies

Nurul Adha Sari, Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Muslim Indonesia, Makassar, Indonesia

Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Muslim Indonesia, Makassar, Indonesia

Sri Julyani, Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

https://scholar.google.com

Muhammad Wirawan Harahap, Departemen Anestesi, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

Departemen Anestesi, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

https://scholar.google.com

Irmayanti Haidir Bima, Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

https://scholar.google.com

Abdul Mubdi Ardiansar Arifuddin, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Muslim Indonesia, RSP Ibnu Sina YW-UMI, Makassar, Indonesia

https://scholar.google.com

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