Relationship between manganese minerals and type 2 diabetes mellitus
DOI:
https://doi.org/10.36590/akg.v1i1.818Keywords:
Dietary manganese (Mn), Manganese (Mn) levels, Type-2 DMAbstract
Indonesia is the fourth country with the largest prevalence of DM in the world which is caused by an unhealthy lifestyle. Risk factors for DM that cannot be modified include race, ethnicity, age, gender, genetics from a family with DM, history of giving birth >4 kg and LBW <2.5 kg. Meanwhile risk factors that can be modified include overweight, abdominal/central obesity, lack of physical activity, high blood pressure (hypertension), dyslipidemia, high calorie and unbalanced diet, prediabetes with impaired blood glucose tolerance levels (IGT 140 -199 mg/dl) or impaired fasting blood glucose levels (GDPT <140 mg/dl) as well as smoking habits. Several studies have revealed that dietary manganese is related to type 2 DM. However, the relationship between manganese diet and type 2 DM in women cannot yet be explained through a definite pathophysiological pathway after all confounding variables have been adjusted for, so it still needs to be studied further, especially regarding manganese analysis methods in assessing manganese status. which is usually based on the concentration of manganese in plasma/serum and all blood components.
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References
Aschner, JL., & Aschner, M. (2005). Nutritional aspects of manganese homeostasis. Molecular Aspects of Medicine, 26(4–5), 353–362.
Baly, DL., Curry, DL., Keen, CL., & Hurley, LS. (1984). Effect of manganese deficiency on insulin secretion and carbohydrate homeostasis in rats. The Journal of Nutrition, 114(8), 1438–1446.
Baquer, NZ., Hothersall, JS., Greenbaum, AL., & McLean, P. (1975). The modifying effect of manganese on the enzymic profiles and pathways of carbohydrate metabolism in rat liver and adipose tissue during development. Biochemical and Biophysical Research Communications, 62(3), 634–641.
Bucher, T., Weltert, M., Rollo, ME., Smith, SP., Jia, W., Collins, CE., & Sun, M. (2017). The international food unit: A new measurement aid that can improve portion size estimation. International Journal of Behavioral Nutrition and Physical Activity, 14(1). https://doi.org/10.1186/s12966-017-0583-y
Cho, N., Shaw, JE., Karuranga, S., Huang, Y. da, da Rocha Fernandes, JD., Ohlrogge, AW., & Malanda, B. (2018). IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Research and Clinical Practice, 138, 271–281.
Du, S., Wu, X., Han, T., Duan, W., Liu, L., Qi, J., Niu, Y., Na, L., & Sun, C. (2018). Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China. Diabetologia, 61(9), 1985–1995.
Eshak, ES., Muraki, I., Imano, H., Yamagishi, K., Tamakoshi, A., & Iso, H. (2021). Manganese intake from foods and beverages is associated with a reduced risk of type 2 diabetes. Maturitas, 143, 127–131.
Folsom, AR., Ma, J., Eckfeldt, JH., Nieto, FJ., Metcalf, PA., Barnes, RW., & Investigators, AR. in C. (ARIC) S. (1995). Low serum albumin: association with diabetes mellitus and other cardiovascular risk factors but not with prevalent cardiovascular disease or carotid artery intima-media thickness. Annals of Epidemiology, 5(3), 186–191.
Gong, JH., Lo, K., Liu, Q., Li, J., Lai, S., Shadyab, AH., Arcan, C., Snetselaar, L., & Liu, S. (2020). Dietary Manganese, Plasma Markers of Inflammation, and the Development of Type 2 Diabetes in Postmenopausal Women: Findings From the Women’s Health Initiative. Diabetes Care, 43(6), 1344–1351.
Gropper, SS., & Smith, JL. (2012). Advanced nutrition and human metabolism. Cengage Learning.
Hardy, G. (2009). Manganese in parenteral nutrition: who, when, and why should we supplement? Gastroenterology, 137(5), S29–S35.
Kemenkes. (2013). Riset Kesehatan Dasar (RISKESDAS) 2013. https://labmandat.litbang.kemkes.go.id/images/download/laporan/RKD/2013/Laporan_riskesdas_2013_final.pdf
Kemenkes. (2018). Laporan Nasional RISKESDAS 2018. https://labmandat.litbang.kemkes.go.id/menu-download/menu-download-laporan
Kemenkes. (2019). Angka kecukupan gizi yang dianjurkan untuk masyarakat indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia.
Koh, ES., Kim, S. J., Yoon, HE., Chung, JH., Chung, S., Park, CW., Chang, YS., & Shin, SJ. (2014). Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population. BMC Endocrine Disorders, 14(1), 1–8.
Lee, SH., Jouihan, HA., Cooksey, RC., Jones, D., Kim, HJ., Winge, DR., & McClain, DA. (2013). Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. Endocrinology, 154(3), 1029–1038.
Li, L., & Yang, X. (2018). The essential element manganese, oxidative stress, and metabolic diseases: links and interactions. Oxidative Medicine and Cellular Longevity, 2018.
Luo, J. (2001). Manganese Superoxide Dismutase (MnSOD). B-180 Medical Laboratories Free Radical and Radiation Biology Program The University of Iowa, 1–10.
Malecki, EA., & Greger, JL. (1996). Manganese protects against heart mitochondrial lipid peroxidation in rats fed high levels of polyunsaturated fatty acids. The Journal of Nutrition, 126(1), 27–33.
Maritim, AC., Sanders, aRA, & Watkins Iii, JB. (2003). Diabetes, oxidative stress, and antioxidants: a review. Journal of Biochemical and Molecular Toxicology, 17(1), 24–38.
Mathers, C., Stevens, G., & Mascarenhas, M. (2009). Global health risks: mortality and burden of disease attributable to selected major risks. World Health Organization.
Oulhote, Y., Mergler, D., & Bouchard, MF. (2014). Sex-and age-differences in blood manganese levels in the US general population: national health and nutrition examination survey 2011–2012. Environmental Health, 13(1), 1–10.
Rucker, D., Thadhani, R., & Tonelli, M. (2010). Trace element status in hemodialysis patients. Seminars in Dialysis, 23(4), 389–395.
Sachse, B., Kolbaum, AE., Ziegenhagen, R., Andres, S., Berg, K., Dusemund, B., Hirsch‐Ernst, KI., Kappenstein, O., Müller, F., & Röhl, C. (2019). Dietary Manganese Exposure in the Adult Population in Germany—What Does it Mean in Relation to Health Risks? Molecular Nutrition & Food Research, 63(16), 1900065.
Trumbo, P., Yates, AA., Schlicker, S., & Poos, M. (2001). Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Journal of the American Dietetic Association, 101(3), 294–301.
Wang, X., Zhang, M., Lui, G., Chang, H., Zhang, M., Liu, W., Li, Z., Liu, Y., & Huang, G. (2016). Associations of serum manganese levels with prediabetes and diabetes among≥ 60-year-old Chinese adults: a population-based cross-sectional analysis. Nutrients, 8(8), 497.
Yamada, M., Asakura, K., Sasaki, S., Hirota, N., Notsu, A., Todoriki, H., Miura, A., Fukui, M., & Date, C. (2014). Estimation of intakes of copper, zinc, and manganese in Japanese adults using 16-day semi-weighed diet records. Asia Pacific Journal of Clinical Nutrition, 23(3), 465–472.
Ye, Q., Park, J. E., Gugnani, K., Betharia, S., Pino-Figueroa, A., & Kim, J. (2017). Influence of iron metabolism on manganese transport and toxicity. Metallomics, 9(8), 1028–1046.

