PlGF Levels and Blood Pressure in Pregnant Women with Hypertension
DOI:
https://doi.org/10.36590/jika.v6i1.647Keywords:
hypertension in pregnancy, blood pressure, PlGFAbstract
Hypertension in pregnancy is one of the causes of morbidity and mortality in mothers and babies. PlGF has been shown to be associated with the diagnosis of hypertensive disorders in pregnancy. Pregnant women with hypertension are characterized by reduced circulating PlGF levels, even before clinical signs and symptoms. A decrease in the amount of PlGF is positively correlated with the severity of disease progression This study aimed to analyze the relationship between PlGF levels and blood pressure in pregnant women with hypertension. Observational analytic with cross sectional study design. Sampling was total sampling. The number of subject were 34 peoples. The results showed that there was no significant correlation between PlGF levels and blood pressure in pregnant women with hypertension. PlGF levels have no relationship with blood pressure.
Downloads
References
Agrawal S, Shinar S, Sofia A, Redman C, Vathis M. 2019. Predictive Performance of PlGF (Placental Growth Factor) for Screening Preeclampsia in Asymptomatic Women: A Systematic Review and Meta-analysis. Hypertension, 74(5): 1124-1135. https://doi.org/10.1161/HYPERTENSIONAHA.119.13360
Akbar MIA, Adibrata AM, Adityawarman, Aryananda RA, Angsar MD, Dekker G. 2019. Maternal and Perinatal Outcome Related to Severity of Chronic Hypertension in Pregnancy. Elsevier, 16, 154-160. https://doi.org/10.1016/j.preghy.2019.04.007.
Albonici L, Benvenuto M, Foccaccetti C, Cifaldi L, Tony M, Limana F, Manzari V, Bei R. 2020. PlGF Immunological Impact During Pregnancy. International Journal of Molecular Sciences, 21(22), 1-26. https://doi.org/10.3390/ijms21228714.
Antwi E, Coleman MA, Viera DL, Madhavaram S, Koram KA, Grobbe DE, Agyepong GA, Groubucsh K. 2020. Systematic Review of Prediction Models for Gestational Hypertension and Preeclampsia. Plos One, 15(4), 1-24. https://doi.org/10.1371/JOURNAL.PONE.0230955.
Birdir C, Droste L, Fox L, Frank M, Fryze J, Enekwe A, K?ninger A, Kimmig R, Shcmidth B, Gellhaus A. 2018. Predictive Value of sFlt-1, PlGF, sFlt-1/PlGF Ratio and PAPP-A for Late-Onset Preeclampsia and IUGR Between 32 and 37?Weeks of Pregnancy. Elsivier, 12, 124-128. https://doi.org/10.1016/j.preghy.2018.04.010
Birukov A, Herse F, Nielsen JH, Henriette B, Golich M, Kraker K, Haase N, Busjhans A, Bruun S. 2020. Blood Pressure and Angiogenic Markers in Pregnancy Contributors to Pregnancy-Induced Hypertension and Offspring Cardiovascular Risk. Hypertension, 76(3), 901-909. https://doi.org/10.1161/HYPERTENSIONAHA.119.13966
Black C, Al Amin A, Stolarek C, Rolnik DL, White A, Costa FDS, Brennecke N. 2019. Midpregnancy Prediction of Pre-Eclampsia Using Serum Biomarkers sFlt-1 and PlGF. Hypertension, 16, 112-119. https://doi.org/10.1016/j.preghy.2019.03.009
Braunthal S, Brateanu A. 2019. Hypertension in Pregnancy: Pathophysiology and Treatment. Sage Journals, 7, 1-15. https://doi.org/10.1177/2050312119843700
Chau K, Hennessy A, Makris A. 2017. Placental Growth Factor and Pre-Eclampsia. Journal of Human Hypertension, 31(12), 782-786. https://doi.org/10.1038/JHH.2017.61
Felicia Sunjaya A, Paulo Sunjaya A. 2019. Evaluation of Serum Biomarkers and Other Diagnostic Modalities for Early Diagnosis of Preeclampsia. Journal of Family and Reproductive Health, 13(2), 56-69. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969892/
Kartika Sari, N, Hakimi M, Baning Rahayujati T. 2016. Determinan Gangguan Hipertensi Kehamilan di Indonesia. Berita Kedokteran Masyarakat, 32 (9), 295-302. https://doi.org/10.22146/bkm.12414
Khalil A, Muttukrishna S, Harrington K, Jauniaux E. 2008. Effect of Antihypertensive Therapy with Alpha Methyldopa on Levels of Angiogenic Factors in Pregnancies with Hypertensive Disorders. Plos One, 3(7), 1-8. https://doi.org/10.1371/JOURNAL.PONE.0002766.
Lecarpentier E, ZSengngeller ZK, Salahuddin S, Covarrubias A, Agnes L, Haddad B. 2020. Total Versus Free Placental Growth Factor Levels in the Pathogenesis of Preeclampsia. Hypertension, 76(3), 875-883. https://doi.org/10.1161/HYPERTENSIONAHA.120.15338
Liu N, Guo YN, Gong LK, Sung Whang B. 2021. Advances in Biomarker Development and Potential Application for Preeclampsia Based on Pathogenesis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 9, 1-9 https://doi.org/10.1016/j.eurox.2020.100119
Makris A, Yeung KR, M Lim S, Sunderland N, Heffernan S, Thompson J, Iliopoulus J. 2016. Placental Growth Factor Reduces Blood Pressure in a Uteroplacental Ischemia Model of Preeclampsia in Nonhuman Primates. Hypertension, 67(6), 1263-1272. https://pubmed.ncbi.nlm.nih.gov/27091894/.
McLaughlin K, Snelgrof JW, Melani C, Sebastian D, Syad A. 2021. PlGF (Placental Growth Factor) Testing in Clinical Practice: Evidence from a Canadian Tertiary Maternity Referral Center. Hypertension, 77(6), 2057-2065. https://doi.org/10.1161/HYPERTENSIONAHA.121.17047.
Parchem JG, Konasaki K, Kanasaki M, Sugimoto H, Xie L, Hamano Y, Bong Le S, Gattone VH. 2018. Loss of Placental Growth Factor Ameliorates Maternal Hypertension and Preeclampsia in Mice. The Journal of Clinical Investigation, 128(11), 5008-5017. https://doi.org/10.1172/JCI99026.
Say L, Doris Cou MD, Allison G, Tuncalp O, Moller AB. 2014. Global Causes of Maternal Death: A WHO Systematic Analysis. The Lancet Global Health, 2(6), 323-333. https://doi.org/10.1016/S2214-109X(14)70227-X
Selvarajan S, Ramalingam J, Venugopal V. 2023. Soluble FMS-Like Tyrosine Kinase-1: An Overview. International Journal of Medical Biochemistry, 6(2), 117-123. https://doi.org/10.14744/ijmb.2023.66933
Spradley FT, Adelene YT, S Joo W, Daniels G, Kussie P, Karumanci SA, Granger S. 2016. Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension. Hypertension, 67(4), 740-747. https://pubmed.ncbi.nlm.nih.gov/26831193/
Turpin CA, Samuel S, Owiredu W, Ephraim R, Anto Enoh O. 2015. Association Between Adverse Pregnancy Outcome and Imbalance in Angiogenic Regulators and Oxidative Stress Biomarkers in Gestational Hypertension and Preeclampsia. BMC Pregnancy and Childbirth, 15(189), 1-10. https://doi.org/10.1186/s12884-015-0624-y
Ukah UV, Jenifer A, Payne B, Haslam MD. 2017. Placental Growth Factor as A Prognostic Tool in Women with Hypertensive Disorders of Pregnancy a Systematic Review. Hypertension, 70(6), 228-1237. https://doi.org/10.1161/HYPERTENSIONAHA.117.10150.
Wang W, Du T, Jiang X. 2021. Correlation Between 25-Hydroxyvitamin D, sFLT-1, PLGF, and Hypertension in Pregnancy. Journal of Healthcare Engineering, 2021, 1-11. https://doi.org/10.1155/2021/9371953.
Wu Y, Wang, Zhang. 2020. Regulation of Magnesium Sulfate Combined with Nifedipine and Labetalol on Disease-Related Molecules in Serum and Placenta in The Treatment of Preeclampsia. European Review for Medical and Pharmacological Sciences, 24(9), 5062-5070. https://doi.org/10.26355/eurrev_202005_21199.
Yeni CM, Fauziah PN, Maskoen AM, Ruslami R, Mose J. 2020. Effect of Curcumin on sFlt-1 and PlGF Concentration in Preeclampsia Induced HUVEC Cell Line. Systematic Reviews in Pharmacy, 11(11), 1247-1251. https://www.sysrevpharm.org/abstract/effect-of-curcumin-on-sflt1-and-plgf-concentration-in-preeclampsia-induced-huvec-cell-line-66681.html
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Veronica Simanjuntak, Runjati, Suharsono, Arwani
This work is licensed under a Creative Commons Attribution 4.0 International License.